Böhm, Hans-Reinhard Zerkowski and Otto-Erich Brodde
نویسندگان
چکیده
Klaus Pönicke, Magdalene Vogelsang, Moritz Heinroth, Karin Becker, Oliver Zolk, Michael Endothelin Receptors in the Failing and Nonfailing Human Heart Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 1998 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.97.8.744 1998;97:744-751 Circulation. http://circ.ahajournals.org/content/97/8/744 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Cardiac Muscarinic Receptors Decrease with Age
The M 1 muscarinic receptor antagonist pirenzepine in low doses decreases resting heart rate; this effect declines with age (Poller, U., G. Nedelka, J. Radke, K. Pönicke, and O.-E. Brodde. 1997. J. Am. Coll. Cardiol. 29:187–193). To study possible mechanisms underlying this effect, we assessed ( a ) in six young (26 yr old) and six older volunteers (61 yr old), pirenzepine effects (0.32 and 0.6...
متن کاملHeinroth-Hoffmann and Otto-Erich Brodde
Treatment of rats with monocrotaline (MCT) leads to pulmonary hypertension, right ventricular (RV) hypertrophy, and finally to RV heart failure. This is associated with characteristic changes in right ventricular -adrenoceptors ( -AR), neuronal noradrenaline transporter (NAT) density and activity (uptake1), and G protein– coupled receptor kinase (GRK) activity. This study aimed to find out fact...
متن کاملAge-dependent changes of cardiac neuronal noradrenaline reuptake transporter (uptake1) in the human heart.
OBJECTIVES The purpose of this study was to elucidate whether the neuronal noradrenaline reuptake transporter (uptake1) undergoes age-dependent regulation in the human heart. BACKGROUND Aging is associated with various alterations in cardiovascular function. METHODS We determined uptake1 density (by [3H]-nisoxetine binding to membranes) and activity (by accumulation of [3H]-noradrenaline in...
متن کاملUnchanged G-protein-coupled receptor kinase activity in the aging human heart.
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Determining which proteins are unique among one or several protein populations is an often-encountered task in proteomics. To this purpose, we present a new method based on trypsin-catalyzed incorporation of the stabile isotope (18)O in the C-termini of tryptic peptides, followed by LC-MALDI MS analysis. The analytical strategy was designed such that proteins unique to a given population out of...
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تاریخ انتشار 1998